Using High-Throughput Sequencing to Investigate the Transgenerational Effects of Endocrine-Disrupting Compound Bisphenol A on Gene Transcription in Sexually Dimorphic Mouse Brain Regions MPOA and BNST
نویسندگان
چکیده
I am currently engaged in an NIH-funded research project with faculty at The University of Virginia and North Carolina State University that investigates the transgenerational effects of the plastic component, bisphenol A (BPA), on gene transcription in two regions of the brain: the medial preoptic area (MPOA) of the hypothalamus and the bed nucleus of the stria terminalis (BNST). My participation in this work has been generously supported by both the James Madison University and University of Virginia 4-VA programs.
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Bisphenol A (BPA) is a plasticizer and an endocrine-disrupting chemical. It is present in a variety of products used daily including food containers, paper, and dental sealants and is now widely detected in human urine and blood. Exposure to BPA during development may affect brain organization and behavior, perhaps as a consequence of its actions as a steroid hormone agonist/antagonist and/or a...
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تاریخ انتشار 2015